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What's the Difference

Mirth Connect vs. InterSystems: Simplicity Meets Powerful Integration

Choose interoperability without complexity. See how Mirth Connect offers transparent pricing, intuitive tools, and rapid deployment, without the heavy learning curve or unpredictable licensing of InterSystems’ platforms.

Built for Any Size Team—Not Just Enterprises

Mirth Connect gives your team more ways to scale

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Small Practices & Clinics

Lightweight, affordable, self-managed
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Mid-Size Medical Groups

Extensible, flexible and highly efficient
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Large Health Systems

Mirth Command Center* + Scalable, flexible architecture and robust security
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Integration Vendors & OEMs

API-enabled, AI-ready, customizable, secure

What sets Mirth Connect apart

Feature / Benefit Mirth Connect by NextGen Healthcare Common Competitors
Licensing Transparent pricing based on your environment, no surprises or per-endpoint fees. Licensed per “Core,” with complex, variable pricing models that can escalate quickly.
Ideal Use Designed for small to large healthcare organizations, integration vendors, and OEMs. Built for large, data-heavy enterprises; may be overkill for simpler integration needs.
Developer Control Flexible scripting, open customization, and developer-friendly tools included out-of-the-box. Limited native scripting and less intuitive development experience.
Ease of Use Intuitive interface with low learning curve; fast onboarding and deployment. Steep learning curve and complex configuration requirements.
Scalability Scales easily with built-in clustering and deployment options, no special licensing required. Scalable but may require specialized setup and licensing for advanced use.
Customization Highly customizable with open-source flexibility. Customization can be limited or requires complex development.
Deployment Flexibility Deploy on-premise, in the cloud, or hybrid with consistent performance. Deployment flexibility is limited or complex to configure.
Monitoring & Alerting Built-in monitoring and alerts for proactive issue detection. Available, but may require additional setup or third-party add-ons.
Security Secure communication or data exchange with robust encryption and authentication options. Security features available, though implementation can be complex.
Support Direct access to expert support with no hidden fees. Premium support often requires additional purchase or increased costs.
Availability Commonly used and trusted by healthcare organizations worldwide. Widely adopted by large enterprises and global institutions.

*Mirth Command Center is currently only available in the United States. The information presented in this table is for general comparison purposes only and is not intended to represent the full scope of features, pricing, or performance of any single competitor. Details are based on publicly available information as of the date of publication and may not reflect the most current offerings. Readers should verify information directly before making decisions.

The channels and features within Mirth Connect allow you to build integrations quickly. If I’m asked on Monday to integrate a new system into the hospital network, it will be installed and ready for testing in a week.

Óscar González
Software Analyst Bahía Software

FAQs

Common Questions

You’re not the only one asking these…

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NextGen Healthcare clients have outstanding outcomes with our solutions.
Enable patients to use step-by-step scheduling on a web-enabled device.
  • Is Mirth still open source

    The legacy open-source version remains available but is no longer maintained. The commercial version provides a superior experience with ongoing updates, enhanced features, and dedicated support.
  • How does Mirth scale compared to InterSystems?

    Mirth Connect scales effortlessly through multi-instance deployments and advanced clustering, providing high availability and strong performance across distributed environments. Unlike InterSystems’ solutions, which may require complex setup and additional licensing for scalability, Mirth Connect gives you full control without the need for specialized infrastructure or opaque configuration layers.

    A doctor viewing information on his laptop computer
  • What if my team has strong developer skills?

    Mirth Connect is ideal for developers, offering full scripting in Java and JavaScript, customizable connectors, and API-driven workflows. Your team can tailor integrations, embed business logic, and scale deployments without sacrificing security or being limited by a black-box platform. 
  • Can I run Mirth Connect in the cloud or manage multiple servers?

    Yes. Mirth Connect is cloud-agnostic and supports multi-instance environments. With Mirth Command Center, you get centralized visibility across environments, whether hosted on-prem, in your private cloud, or with a managed service provider.
  • Do I lose support compared to InterSystems?

    Not at all. Mirth Connect includes expert support as part of your package, no extra purchase required. With InterSystems, premium support often comes with additional costs. Mirth Connect ensures you get responsive, world-class assistance without hidden fees or tiered service models.
    NextGen Healthcare clients have outstanding outcomes with our solutions.
  • What’s different between Mirth Connect and the open-source forks?

    Open-source forks are no longer maintained by NextGen Healthcare and rely entirely on third-party developers, raising concerns around security, stability, and long-term viability. These forks lack critical enterprise features like the Mirth Command Center, multi-factor authentication (MFA), and the SSL generator, and they offer no official support. In contrast, the commercial version of Mirth Connect is actively developed by NextGen Healthcare, backed by high-quality support, and includes a robust roadmap for innovation.
  • Is there a Mirth solution for clinical researchers?

    Mirth Connect for Research is a complimentary license for active studies linked to non-profit research institutions. Learn more here.
    Enable patients to use step-by-step scheduling on a web-enabled device.
Testimonials

What do practices say about Mirth Connect

why teams choose mirth
Why Teams Choose Mirth Over Rhapsody

Built for Builders. Ready for What’s Next.

Mirth Connect continues to be the integration engine of choice for teams who demand flexibility, control, and results. In 2025, the new commercial model unlocks faster innovation, enterprise-grade security, and a modernized user experience.

With the introduction of the Mirth Command Center, Mirth Connect now delivers a complete, cloud-ready platform that combines developer power with operational simplicity. From HL7 message generation to SSL encryption, MFA, and real-time monitoring, Mirth Connect is purpose-built for healthcare interoperability at scale. Whether you're a nimble startup or a large-scale enterprise, Mirth Connect equips your team with the tools to move fast, stay secure, and grow with confidence.
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Performance & ROI

Enterprise-level outcomes, without enterprise-level costs

Mirth Connect powers millions of real-time messages daily, supporting some of the largest health systems in the world. In fact, a large percentage of Mirth usage comes from health IT vendors, who rely on its flexible architecture for both EHR integration and third-party data pipelines. Its modular design reduces infrastructure sprawl, improves security, and adapts to your unique workflows.
Don’t trade flexibility for complexity.

Mirth Connect is ready for your integration challenges.